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This observation of higher calcium influx in BD is intriguing in the context of iron overload since calcium and iron have a bidirectional relationship where high Ca +2 influx causes increased LIP and iron overload promotes massive Ca +2 influx [145, 146]

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Loss-of-function jet mutants show impaired phase shifts in response to light pulses, slower re-entrainment to shifted light-dark cycles, and stabilized tim protein levels under light conditions ( jet in clock neurons