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The most adverse effects were observed in the kidney due to a significant increase in the inflammatory biomarkers MCP-1 and IL-6 at a dose of 100 mg/kg bw/day and TNF-, resistin and PAI-1 were significantly increased at a dose of 100 mg/kg bw/day, 100 mg/kg bw/day, and 200 mg/kg bw/day, respectively (Figure 5)

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These complementary pathways allow investigators to explore how cytoskeletal status, vascular signaling, and inflammatory mediators interact in broader cellular response networks

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