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Johnston BA

BaisSRanaRKDongreNGoyanarGPanwarASSoniAKet al

Another critical knowledge gap lies in the integration of GSH metabolism with metal handling and mitochondrial function

While direct evidence in human tinnitus tissue is scarce and no study has yet demonstrated HDAC isoform alterations specifically in the AC in tinnitus models, pharmacological inhibition of HDAC3 in the AC has been shown to accelerate learning and strengthen cortical encoding of behaviorally relevant sounds, demonstrating that HDAC-mediated mechanisms can directly regulate AC plasticity (Ateyakar and Bieszczad, 2026)