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Phase 2 trial (NEJM 2023) randomized 338 adults with obesity to retatrutide doses from 1 mg to 12 mg/week

Researchers observed that dairy cows harboring a Bifidobacterium -dominated enterotype exhibited faster recovery following LPS challenge, with accelerated restoration of SCFAs, enhanced amino acid metabolism, improved glucose homeostasis, and higher milk fat and protein content compared to other enterotypes, suggesting that intrinsic microbiome configurations may determine host resilience to inflammatory challenges 94

Andrew Huberman: Yeah, very hard to measure dopamine directly from the brain unless you're doing microdialysis

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