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[18] [20] Tirzepatide is initiated at 2.5 mg weekly and increased every 4 weeks as tolerated to a maximum dose of 15 mg weekly

The second mechanism is through the interaction between glutamate and the cystine transporter, which reduces intracellular glutathione (GSH) and increases ROS accumulation

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Among them, fatty acid translocase (CD36, FAT), fatty acid transport protein family [FATPs, solute carrier protein family 27 (SLC27)] and plasma membrane fatty acid binding protein (FABPPM) all exhibit high levels of gene and protein expression in tumors (61)