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Emerging research suggests that glycine may become conditionally indispensable (dietarily essential) during the third trimester, yet this physiological need does not imply that high-dose injections are recommended.Similar caution applies during lactation: while glycine is naturally present in breast milk, the impact of pharmacologic doses is unknown

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Patients frequently experience: Fatigue and generalised weakness that persists despite adequate rest Breathlessness on exertion due to anaemia Palpitations and reduced exercise tolerance Pallor of the skin and mucous membranes These symptoms result from megaloblastic anaemia, where impaired DNA synthesis leads to the production of abnormally large, dysfunctional red blood cells with reduced oxygen-carrying capacity