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The HTH motif is followed by a large C-terminal regulatory domain (49) that incorporates a number of independently evolved ligand binding cavities that are readily accessible from the side, front, or top of the homodimer

For instance, alcohol inhibits nutrient absorption, especially for B vitamins

J Pharmacol Exp Ther 187:211217 Muldrew KL, James LP, Coop L, McCullough SS, Hendrickson HP, Hinson JA, Philip R, Mayeux PR (2002) Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection

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