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These compositional shifts are accompanied by elevated levels of uremic toxins (IS, PCS, indole, and p-cresol) and secondary bile acids derived from aromatic amino acid degradation and microbial secondary bile acid biosynthesis ( Table 1 ) [110]

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Disrupting melanosome transport may also induce autophagy-mediated degradation of accumulating melanosomes, which can contribute to the decrease of melanin content in cells [126]

Exploring the pivotal immunomodulatory and anti-inflammatory potentials of glycyrrhizic and glycyrrhetinic acids