To overcome this limitation and develop new therapeutic strategies, generating an experimental model reflecting human renal Fabry disease is essential
[3] The Endocrine Society guideline recommends 3,000 to 6,000 IU/day for adults over 70 to maintain 25-OH D above 30 ng/mL
What matters most is supplier qualification, manufacturing controls, domestic formulation and lyophilization, and independent third-party testing
Mechanistically, SLC25A39 deficiency induced mitochondrial dysfunction, characterized by excessive mitochondrial reactive oxygen species (ROS), reduced membrane potential, diminished adenosine triphosphate (ATP) synthesis, aberrant mitochondrial permeability transition pore (mPTP) opening, and cytochrome c release