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It contains a DExD/H-box RNA helicase domain and a C-terminal domain (CTD) that bind dsRNA, along with two N-terminal caspase activation and recruitment domains (CARDs) that interact with the mitochondrial antiviral signaling protein (MAVS) to induce transcription of type I IFNs and downstream IFN-stimulated genes (ISGs) (99, 103)

Pathological analysis showed that B5-1@siTNF- treatment in mice with lung inflammation preserved alveolar architecture, reduced bronchial wall thickness, and significantly decreased infiltration of inflammatory cells ( Figure 2F )

Dermatologically evaluated with a skin irritation score of 0.00 and classified as non-irritating (Excellent) after a 24-hour patch application.

When this regulation is disrupted, proinflammatory mediators produced in the gut environment are more likely to enter systemic circulation and affect distant tissues