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It could protect against endothelial senescence and maintain cell function via the Akt/eNOS/VEGF axis [85]
Dosage variation depends on body mass scaling factors, target purpose (soft tissue recovery focus or tendon repair focus), administration route selection (subcutaneous delivery or intramuscular delivery), and reconstitution concentration, affecting injection volume per dose
Additional models: cartilage, endocrine, kidney In cartilage/chondrocyte culture models: FOXO4-DRI reduced the number of senescent chondrocytes significantly, while healthy chondrocytes remained intact
Among the majority of clinical isolates, specifically 86.7% of isolates, the FICI for the combination of GSH and meropenem approached 0.5, denoting an additive effect (Table 3)
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